Assay Detail
Functional
CHEMBL648938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
(6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.59 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2079787 | — | — | 1 | 8.70 |
| CHEMBL24224 | — | — | 1 | 8.70 |
| CHEMBL2079788 | — | — | 1 | 8.70 |
| CHEMBL2079790 | — | — | 1 | 8.70 |
| CHEMBL2079791 | — | — | 1 | 8.70 |
| CHEMBL2079789 | — | — | 1 | 8.52 |
| CHEMBL24266 | — | — | 1 | 8.52 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.52 |
| CHEMBL2079785 | — | — | 1 | 8.40 |
| CHEMBL284704 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2079787 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL24224 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2079788 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2079790 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2079791 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2079789 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL24266 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL191 | LOSARTAN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2079785 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL284704 | — | IC50 | = | 4.0 | nM | 8.40 |