Assay Detail
Binding
CHEMBL648940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibitory activity against angiotensin I converting enzyme
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and physicochemical properties of a novel, conformationally restricted 2,3-dihydro-1,3,4-thiadiazole-containing angiotensin converting enzyme inhibitor which is preferentially eliminated by the biliary route in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.10 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342372 | UTIBAPRILAT | 2.0 | 1 | 9.29 |
| CHEMBL138409 | — | — | 1 | 9.22 |
| CHEMBL139140 | — | — | 1 | 9.15 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 9.02 |
| CHEMBL423916 | — | — | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342372 | UTIBAPRILAT | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL138409 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL139140 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL423916 | — | IC50 | = | 1.5 | nM | 8.82 |