Assay Detail
Binding
CHEMBL648991
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Displacement of [125I]HEAT from COS cells membranes expressing human Alpha-1B adrenergic receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel thiophene derivatives for the treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.14 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69848 | — | — | 1 | 6.59 |
| CHEMBL67713 | — | — | 1 | 6.42 |
| CHEMBL305029 | — | — | 1 | 6.38 |
| CHEMBL68241 | — | — | 1 | 6.23 |
| CHEMBL421297 | — | — | 1 | 6.21 |
| CHEMBL67932 | — | — | 1 | 6.12 |
| CHEMBL302495 | — | — | 1 | 5.97 |
| CHEMBL418882 | — | — | 1 | 5.73 |
| CHEMBL66823 | — | — | 1 | 5.59 |
| CHEMBL69339 | — | — | 1 | - |
| CHEMBL70178 | — | — | 1 | - |
| CHEMBL420184 | — | — | 1 | - |
| CHEMBL303485 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69848 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL67713 | — | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL305029 | — | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL68241 | — | Ki | = | 592.0 | nM | 6.23 |
| CHEMBL421297 | — | Ki | = | 615.0 | nM | 6.21 |
| CHEMBL67932 | — | Ki | = | 757.0 | nM | 6.12 |
| CHEMBL302495 | — | Ki | = | 1063.0 | nM | 5.97 |
| CHEMBL418882 | — | Ki | = | 1878.0 | nM | 5.73 |
| CHEMBL66823 | — | Ki | = | 2569.0 | nM | 5.59 |
| CHEMBL69339 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL70178 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL420184 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL303485 | — | Ki | > | 5000.0 | nM | - |