Assay Detail
Binding
CHEMBL649063
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Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rabbit intestine microsomes
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Acyl-CoA:cholesterol acyltransferase (CHEMBL6141) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.03 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278856 | — | — | 1 | 7.89 |
| CHEMBL23602 | — | — | 1 | 7.70 |
| CHEMBL23476 | — | — | 1 | 7.62 |
| CHEMBL25662 | — | — | 1 | 7.58 |
| CHEMBL23740 | — | — | 1 | 7.52 |
| CHEMBL281777 | — | — | 1 | 7.48 |
| CHEMBL279228 | — | — | 1 | 7.44 |
| CHEMBL424404 | — | — | 1 | 7.40 |
| CHEMBL23976 | — | — | 1 | 7.38 |
| CHEMBL283332 | — | — | 1 | 7.30 |
| CHEMBL23624 | — | — | 1 | 7.23 |
| CHEMBL282451 | — | — | 1 | 7.23 |
| CHEMBL23857 | — | — | 1 | 7.12 |
| CHEMBL423651 | — | — | 1 | 7.09 |
| CHEMBL23340 | — | — | 1 | 7.07 |
| CHEMBL23775 | — | — | 1 | 7.05 |
| CHEMBL25387 | — | — | 1 | 6.92 |
| CHEMBL25712 | — | — | 1 | 6.85 |
| CHEMBL22373 | CL-976 | — | 1 | 6.85 |
| CHEMBL553566 | — | — | 1 | 6.82 |
| CHEMBL282897 | — | — | 1 | 6.77 |
| CHEMBL278578 | — | — | 1 | 6.68 |
| CHEMBL22963 | — | — | 1 | 6.62 |
| CHEMBL278155 | — | — | 1 | 6.58 |
| CHEMBL23111 | — | — | 1 | 6.54 |
| CHEMBL23599 | — | — | 1 | 6.48 |
| CHEMBL282071 | — | — | 1 | 6.40 |
| CHEMBL23084 | — | — | 1 | 6.30 |
| CHEMBL23561 | — | — | 1 | 6.05 |
| CHEMBL281144 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278856 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL23602 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL23476 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL25662 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL23740 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL281777 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL279228 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL424404 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL23976 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL283332 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL23624 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL282451 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL23857 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL423651 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL23340 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL23775 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL25387 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL25712 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL22373 | CL-976 | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL553566 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL282897 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL278578 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL22963 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL278155 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL23111 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL23599 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL282071 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL23084 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL23561 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL281144 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL23782 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL280903 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL422222 | — | IC50 | > | 200.0 | nM | - |