Compound Detail
CHEMBL23857
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Basic Information
| ChEMBL ID | CHEMBL23857 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MHUPDCJBNGBZEU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
472.1
MW (Da)
7.66
ALogP
3
HBA
1
HBD
47.6
PSA (Ų)
0.36
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acyl-CoA:cholesterol acyltransferase CHEMBL6141 | IC50 | 7.12 | 7.12 | 76.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 5.82 | 5.82 | 1500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acyl-CoA:cholesterol acyltransferase | IC50 | = | 76.0 | nM | 7.12 | Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtain... | 8632433 |
| Rattus norvegicus | IC50 | = | 1500.0 | nM | 5.82 | Inhibitory activity against foam cell formation (acetyl-LDL-induced cholesteryl ... | 8632433 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8632433 | 10.1021/jm950828+ | Rattus norvegicus | 3 |
| 8632433 | 10.1021/jm950828+ | Acyl-CoA:cholesterol acyltransferase | 1 |
Data from ChEMBL 36 via Core Engine