Assay Detail
Functional
CHEMBL784316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against foam cell formation (acetyl-LDL-induced cholesteryl ester accumulation) in rat peritoneal macrophages
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.35 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23602 | — | — | 1 | 7.52 |
| CHEMBL278856 | — | — | 1 | 6.80 |
| CHEMBL23976 | — | — | 1 | 6.19 |
| CHEMBL23857 | — | — | 1 | 5.82 |
| CHEMBL22373 | CL-976 | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23602 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL278856 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL23976 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL23857 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL22373 | CL-976 | IC50 | = | 3800.0 | nM | 5.42 |