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Assay Detail

CHEMBL649135

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Binding
Inhibition of fetal Bovine serum AChE
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL4768)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Savini L, Gaeta A, Fattorusso C, Catalanotti B, Campiani G, Chiasserini L, Pellerano C, Novellino E, McKissic D, Saxena A.
J Med Chem (2003) 46 : 1 -4
PubMed 12502352 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.76 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL338755 1 10.22
CHEMBL48643 1 9.00
CHEMBL32823 1 8.89
CHEMBL502 DONEPEZIL 4.0 1 8.54
CHEMBL131386 1 8.43
CHEMBL51350 1 8.22
CHEMBL95 TACRINE 4.0 1 7.40
CHEMBL53927 1 6.82
CHEMBL129719 1 6.68
CHEMBL129108 1 6.60
CHEMBL51197 1 6.47
CHEMBL131410 1 5.82
CHEMBL1206 ETHOPROPAZINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL338755 Ki = 0.06 nM 10.22
CHEMBL48643 Ki = 1.0 nM 9.00
CHEMBL32823 Ki = 1.3 nM 8.89
CHEMBL502 DONEPEZIL Ki = 2.9 nM 8.54
CHEMBL131386 Ki = 3.7 nM 8.43
CHEMBL51350 Ki = 6.0 nM 8.22
CHEMBL95 TACRINE Ki = 40.0 nM 7.40
CHEMBL53927 Ki = 150.0 nM 6.82
CHEMBL129719 Ki = 210.0 nM 6.68
CHEMBL129108 Ki = 250.0 nM 6.60
CHEMBL51197 Ki = 340.0 nM 6.47
CHEMBL131410 Ki = 1500.0 nM 5.82
CHEMBL1206 ETHOPROPAZINE Ki = 173200.0 nM -