Assay Detail
Binding
CHEMBL649344
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Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New deoxynojirimycin derivatives as potent inhibitors of intestinal -glucohydrolases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.08 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 6.82 |
| CHEMBL75971 | — | — | 1 | 6.38 |
| CHEMBL432221 | — | — | 1 | 6.00 |
| CHEMBL121283 | — | — | 1 | 5.60 |
| CHEMBL332802 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL75971 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL432221 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL121283 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL332802 | — | Ki | = | 2600.0 | nM | 5.58 |