Compound Detail
CHEMBL121283
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Basic Information
| ChEMBL ID | CHEMBL121283 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LSSAZCXUMNMRSK-WRWGMCAJSA-N |
3
Targets
5
Activities
1
Assay Types
5
PK Parameters
6
Publications
0
Known Names
Molecular Properties
277.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal CHEMBL3114 | Ki | 8.1 | 7.7067 | 8.0 | 3 |
| Maltase-glucoamylase CHEMBL2074 | Ki | 7.3 | 7.3 | 50.0 | 1 |
| Lysosomal alpha-glucosidase CHEMBL2608 | Ki | 5.6 | 5.6 | 2500.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 4.0 | hr | Rattus norvegicus |
| T1/2 | 0.4 | hr | Homo sapiens |
| T1/2 | 4.0 | hr | Rattus norvegicus |
| T1/2 | 4.0 | hr | Rattus norvegicus |
| T1/2 | 1.4 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal | Ki | = | 8.0 | nM | 8.1 | Tested in vitro for the inhibition constant against rat small intestinal sucrase | - |
| Sucrase-isomaltase, intestinal | Ki | = | 8.0 | nM | 8.1 | Tested in vitro for the inhibition constant against rat small intestinal sucrase | - |
| Maltase-glucoamylase | Ki | = | 50.0 | nM | 7.3 | In vitro inhibition constant against rat small intestinal glucoamylase | - |
| Sucrase-isomaltase, intestinal | Ki | = | 120.0 | nM | 6.92 | Tested in vitro for the inhibition constant against rat small intestinal isomalt... | - |
| Lysosomal alpha-glucosidase | Ki | = | 2500.0 | nM | 5.6 | Tested in vitro for the inhibition constant against human lysosomal alpha-glucos... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00012-7 | Rattus norvegicus | 4 |
| - | 10.1016/S0960-894X(97)00012-7 | Sucrase-isomaltase, intestinal | 3 |
| - | 10.1016/S0960-894X(97)00012-7 | Lysosomal alpha-glucosidase | 1 |
| - | 10.1016/S0960-894X(97)00012-7 | ADMET | 1 |
| - | 10.1016/S0960-894X(97)00012-7 | Unchecked | 1 |
| - | 10.1016/S0960-894X(97)00012-7 | Maltase-glucoamylase | 1 |
Data from ChEMBL 36 via Core Engine