Assay Detail
Binding
CHEMBL683914
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In vitro inhibition constant against rat small intestinal glucoamylase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New deoxynojirimycin derivatives as potent inhibitors of intestinal -glucohydrolases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.87 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432221 | — | — | 1 | 8.64 |
| CHEMBL120226 | — | — | 1 | 8.40 |
| CHEMBL120488 | — | — | 1 | 8.00 |
| CHEMBL332802 | — | — | 1 | 7.55 |
| CHEMBL121283 | — | — | 1 | 7.30 |
| CHEMBL120489 | — | — | 1 | 7.16 |
| CHEMBL120395 | — | — | 1 | 7.06 |
| CHEMBL415713 | — | — | 1 | 6.92 |
| CHEMBL330763 | — | — | 1 | 6.05 |
| CHEMBL121223 | — | — | 1 | 6.00 |
| CHEMBL120169 | — | — | 1 | 5.60 |
| CHEMBL333917 | — | — | 1 | 5.58 |
| CHEMBL323803 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432221 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL120226 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL120488 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL332802 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL121283 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL120489 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL120395 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL415713 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL330763 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL121223 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL120169 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL333917 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL323803 | — | Ki | = | 10000.0 | nM | 5.00 |