Compound Detail
CHEMBL332802
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Basic Information
| ChEMBL ID | CHEMBL332802 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YAEKSAQPMXIOQF-QKPAOTATSA-N |
3
Targets
4
Activities
1
Assay Types
4
PK Parameters
6
Publications
0
Known Names
Molecular Properties
325.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 7.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Maltase-glucoamylase CHEMBL2074 | Ki | 7.55 | 7.55 | 28.0 | 1 |
| Sucrase-isomaltase, intestinal CHEMBL3114 | Ki | 7.19 | 6.635 | 64.0 | 2 |
| Lysosomal alpha-glucosidase CHEMBL2608 | Ki | 5.58 | 5.58 | 2600.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 3.0 | hr | Rattus norvegicus |
| T1/2 | 2.0 | hr | Rattus norvegicus |
| T1/2 | 5.5 | hr | Rattus norvegicus |
| T1/2 | 0.2 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Maltase-glucoamylase | Ki | = | 28.0 | nM | 7.55 | In vitro inhibition constant against rat small intestinal glucoamylase | - |
| Sucrase-isomaltase, intestinal | Ki | = | 64.0 | nM | 7.19 | Tested in vitro for the inhibition constant against rat small intestinal sucrase | - |
| Sucrase-isomaltase, intestinal | Ki | = | 830.0 | nM | 6.08 | Tested in vitro for the inhibition constant against rat small intestinal isomalt... | - |
| Lysosomal alpha-glucosidase | Ki | = | 2600.0 | nM | 5.58 | Tested in vitro for the inhibition constant against human lysosomal alpha-glucos... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00012-7 | Rattus norvegicus | 3 |
| - | 10.1016/S0960-894X(97)00012-7 | Sucrase-isomaltase, intestinal | 2 |
| - | 10.1016/S0960-894X(97)00012-7 | Maltase-glucoamylase | 1 |
| - | 10.1016/S0960-894X(97)00012-7 | Lysosomal alpha-glucosidase | 1 |
| - | 10.1016/S0960-894X(97)00012-7 | ADMET | 1 |
| - | 10.1016/S0960-894X(97)00012-7 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine