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Assay Detail

CHEMBL808826

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested in vitro for the inhibition constant against rat small intestinal sucrase
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Sucrase-isomaltase, intestinal (CHEMBL3114)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

New deoxynojirimycin derivatives as potent inhibitors of intestinal -glucohydrolases
Lesur B, Ducep J, Lalloz M, Ehrhard A, Danzin C
Bioorg Med Chem Lett (1997) 7 : 355 -360
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 7.45 9.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL432221 1 9.82
CHEMBL120226 1 8.52
CHEMBL121283 2 8.10
CHEMBL120395 1 8.00
CHEMBL415713 1 7.80
CHEMBL120488 1 7.77
CHEMBL75971 1 7.70
CHEMBL307429 DUVOGLUSTAT 2.0 1 7.62
CHEMBL120489 1 7.48
CHEMBL120007 1 7.41
CHEMBL121223 1 7.26
CHEMBL332802 1 7.19
CHEMBL330763 1 6.96
CHEMBL120169 1 6.82
CHEMBL333917 1 6.80
CHEMBL331723 1 6.66
CHEMBL332468 1 6.46
CHEMBL323803 1 5.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL432221 Ki = 0.15 nM 9.82
CHEMBL120226 Ki = 3.0 nM 8.52
CHEMBL121283 Ki = 8.0 nM 8.10
CHEMBL121283 Ki = 8.0 nM 8.10
CHEMBL120395 Ki = 10.0 nM 8.00
CHEMBL415713 Ki = 16.0 nM 7.80
CHEMBL120488 Ki = 17.0 nM 7.77
CHEMBL75971 Ki = 20.0 nM 7.70
CHEMBL307429 DUVOGLUSTAT Ki = 24.0 nM 7.62
CHEMBL120489 Ki = 33.0 nM 7.48
CHEMBL120007 Ki = 39.0 nM 7.41
CHEMBL121223 Ki = 55.0 nM 7.26
CHEMBL332802 Ki = 64.0 nM 7.19
CHEMBL330763 Ki = 110.0 nM 6.96
CHEMBL120169 Ki = 150.0 nM 6.82
CHEMBL333917 Ki = 160.0 nM 6.80
CHEMBL331723 Ki = 220.0 nM 6.66
CHEMBL332468 Ki = 350.0 nM 6.46
CHEMBL323803 Ki = 8500.0 nM 5.07