Compound Detail
CHEMBL120395
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Basic Information
| ChEMBL ID | CHEMBL120395 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WASNYRFAHIVQBS-CCCOFDIUSA-N |
2
Targets
3
Activities
1
Assay Types
3
PK Parameters
3
Publications
0
Known Names
Molecular Properties
317.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal CHEMBL3114 | Ki | 8.0 | 7.205 | 10.0 | 2 |
| Maltase-glucoamylase CHEMBL2074 | Ki | 7.06 | 7.06 | 87.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 13.0 | hr | Rattus norvegicus |
| T1/2 | 3.5 | hr | Rattus norvegicus |
| T1/2 | 2.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal | Ki | = | 10.0 | nM | 8.0 | Tested in vitro for the inhibition constant against rat small intestinal sucrase | - |
| Maltase-glucoamylase | Ki | = | 87.0 | nM | 7.06 | In vitro inhibition constant against rat small intestinal glucoamylase | - |
| Sucrase-isomaltase, intestinal | Ki | = | 390.0 | nM | 6.41 | Tested in vitro for the inhibition constant against rat small intestinal isomalt... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00012-7 | Rattus norvegicus | 3 |
| - | 10.1016/S0960-894X(97)00012-7 | Sucrase-isomaltase, intestinal | 2 |
| - | 10.1016/S0960-894X(97)00012-7 | Maltase-glucoamylase | 1 |
Data from ChEMBL 36 via Core Engine