Assay Detail
Binding
CHEMBL649424
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Inhibitory activity measured against alpha-glucosidase of rat intestinal maltase by colorimetric assay using the D-glucose oxidase-peroxidase method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.55 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442258 | — | — | 1 | 6.77 |
| CHEMBL501355 | — | — | 1 | 6.47 |
| CHEMBL87169 | — | — | 1 | 5.80 |
| CHEMBL2115215 | — | — | 1 | 5.34 |
| CHEMBL3084806 | — | — | 1 | 5.32 |
| CHEMBL2093897 | — | — | 1 | 4.82 |
| CHEMBL2114210 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442258 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL501355 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL87169 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2115215 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3084806 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2093897 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2114210 | — | IC50 | = | 46000.0 | nM | 4.34 |