Compound Detail
CHEMBL3084806
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Basic Information
| ChEMBL ID | CHEMBL3084806 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZQVLWTTWYIVORB-APLZJWDSSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
249.3
MW (Da)
-2.09
ALogP
6
HBA
5
HBD
104.4
PSA (Ų)
0.38
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acidic alpha-glucosidase CHEMBL3513 | IC50 | 5.66 | 4.9 | 2200.0 | 5 |
| Maltase-glucoamylase CHEMBL2074 | IC50 | 5.38 | 5.38 | 4200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acidic alpha-glucosidase | IC50 | = | 2200.0 | nM | 5.66 | Inhibitory activity measured against alpha-glucosidase of rat liver lysosomal by... | 9651160 |
| Acidic alpha-glucosidase | IC50 | = | 3000.0 | nM | 5.52 | Inhibitory activity measured against alpha-glucosidase of rat intestinal sucrase... | 9651160 |
| Maltase-glucoamylase | IC50 | = | 4200.0 | nM | 5.38 | Inhibitory activity measured against alpha-glucosidase of rice by colorimetric a... | 9651160 |
| Acidic alpha-glucosidase | IC50 | = | 4800.0 | nM | 5.32 | Inhibitory activity measured against alpha-glucosidase of rat intestinal maltase... | 9651160 |
| Acidic alpha-glucosidase | IC50 | = | 100000.0 | nM | 4.0 | Inhibitory activity measured against alpha-glucosidase of rat intestinal isomalt... | 9651160 |
| Acidic alpha-glucosidase | IC50 | = | 100000.0 | nM | 4.0 | Inhibitory activity measured against alpha-glucosidase of rat liver ER glucosida... | 9651160 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9651160 | 10.1021/jm970836l | Acidic alpha-glucosidase | 5 |
| 9651160 | 10.1021/jm970836l | Maltase-glucoamylase | 1 |
Data from ChEMBL 36 via Core Engine