Assay Detail
Binding
CHEMBL649425
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Inhibitory activity measured against alpha-glucosidase of rat intestinal sucrase by colorimetric assay using the D-glucose oxidase-peroxidase method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.90 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442258 | — | — | 1 | 7.70 |
| CHEMBL501355 | — | — | 1 | 6.77 |
| CHEMBL87169 | — | — | 1 | 6.10 |
| CHEMBL2115215 | — | — | 1 | 5.52 |
| CHEMBL3084806 | — | — | 1 | 5.52 |
| CHEMBL2093897 | — | — | 1 | 5.14 |
| CHEMBL2114210 | — | — | 1 | 4.57 |
| CHEMBL1169500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442258 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL501355 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL87169 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2115215 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3084806 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2093897 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2114210 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1169500 | — | IC50 | = | 410000.0 | nM | - |