Assay Detail
Binding
CHEMBL649493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Angiotensin II induced contractions in rabbit aortic rings
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 9.12 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295854 | — | — | 1 | 10.10 |
| CHEMBL298417 | — | — | 1 | 10.00 |
| CHEMBL7550 | L-158809 | — | 1 | 10.00 |
| CHEMBL42775 | — | — | 1 | 10.00 |
| CHEMBL43500 | — | — | 1 | 9.70 |
| CHEMBL43535 | — | — | 1 | 9.70 |
| CHEMBL288246 | — | — | 1 | 9.70 |
| CHEMBL43424 | — | — | 1 | 9.70 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 9.52 |
| CHEMBL418625 | — | — | 1 | 9.52 |
| CHEMBL290248 | — | — | 1 | 9.52 |
| CHEMBL291043 | — | — | 1 | 9.52 |
| CHEMBL289291 | — | — | 1 | 9.40 |
| CHEMBL297358 | — | — | 1 | 9.40 |
| CHEMBL295928 | — | — | 1 | 9.30 |
| CHEMBL298464 | — | — | 1 | 9.22 |
| CHEMBL42631 | — | — | 1 | 9.15 |
| CHEMBL46822 | — | — | 1 | 9.15 |
| CHEMBL295456 | — | — | 1 | 9.15 |
| CHEMBL429008 | — | — | 1 | 9.10 |
| CHEMBL289448 | — | — | 1 | 9.10 |
| CHEMBL42397 | — | — | 1 | 9.00 |
| CHEMBL42184 | — | — | 1 | 9.00 |
| CHEMBL47187 | — | — | 1 | 8.70 |
| CHEMBL44925 | — | — | 1 | 8.70 |
| CHEMBL289507 | — | — | 1 | 8.70 |
| CHEMBL290907 | — | — | 1 | 8.70 |
| CHEMBL45102 | — | — | 1 | 8.70 |
| CHEMBL45195 | — | — | 1 | 8.70 |
| CHEMBL296472 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295854 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL298417 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL42775 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL7550 | L-158809 | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL43500 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL43535 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL288246 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL43424 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL418625 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL290248 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL291043 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL289291 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL297358 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL295928 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL298464 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL295456 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL42631 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL46822 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL429008 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL289448 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL42397 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL42184 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL45102 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL296472 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL45195 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL290907 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL289507 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL44925 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL47187 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL295929 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL43171 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL295966 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL430570 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL42101 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL42287 | — | IC50 | = | 10.0 | nM | 8.00 |