Compound Detail
CHEMBL429008
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Basic Information
| ChEMBL ID | CHEMBL429008 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XUZIAARJXWYAQV-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
425.5
MW (Da)
4.37
ALogP
7
HBA
2
HBD
105.4
PSA (Ų)
0.40
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor CHEMBL2094256 | IC50 | 9.1 | 8.45 | 0.8 | 2 |
| Angiotensin II receptor (AT-1) type-1 CHEMBL2094250 | IC50 | 8.62 | 8.62 | 2.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin II receptor | IC50 | = | 0.8 | nM | 9.1 | Inhibition of Angiotensin II induced contractions in rabbit aortic rings | 8201597 |
| Angiotensin II receptor (AT-1) type-1 | IC50 | = | 2.4 | nM | 8.62 | Binding affinity against AT1 receptor of rat adrenal cortical membranes | 8201597 |
| Angiotensin II receptor | IC50 | = | 16.0 | nM | 7.8 | Displacement of monoiodinated angiotensin II from guinea-pig adrenal gland angio... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80279-6 | Angiotensin II receptor | 2 |
| 8201597 | 10.1021/jm00037a014 | Angiotensin II receptor (AT-1) type-1 | 1 |
| 8201597 | 10.1021/jm00037a014 | Angiotensin II receptor | 1 |
| - | 10.1007/s00044-012-0040-z | Angiotensin II receptor (AT-1) type-1 | 1 |
Data from ChEMBL 36 via Core Engine