Assay Detail
Binding
CHEMBL652348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against AT1 receptor of rat adrenal cortical membranes
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Intermediate |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.57 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295854 | — | — | 1 | 9.44 |
| CHEMBL295928 | — | — | 1 | 9.22 |
| CHEMBL288246 | — | — | 1 | 9.15 |
| CHEMBL43535 | — | — | 1 | 9.15 |
| CHEMBL418625 | — | — | 1 | 9.15 |
| CHEMBL42775 | — | — | 1 | 9.10 |
| CHEMBL291043 | — | — | 1 | 9.00 |
| CHEMBL46822 | — | — | 1 | 8.96 |
| CHEMBL43424 | — | — | 1 | 8.92 |
| CHEMBL43500 | — | — | 1 | 8.89 |
| CHEMBL297358 | — | — | 1 | 8.89 |
| CHEMBL289291 | — | — | 1 | 8.85 |
| CHEMBL42397 | — | — | 1 | 8.77 |
| CHEMBL289507 | — | — | 1 | 8.72 |
| CHEMBL298417 | — | — | 1 | 8.72 |
| CHEMBL7550 | L-158809 | — | 1 | 8.68 |
| CHEMBL290248 | — | — | 1 | 8.66 |
| CHEMBL296472 | — | — | 1 | 8.66 |
| CHEMBL295456 | — | — | 1 | 8.64 |
| CHEMBL429008 | — | — | 1 | 8.62 |
| CHEMBL298464 | — | — | 1 | 8.49 |
| CHEMBL45195 | — | — | 1 | 8.47 |
| CHEMBL43171 | — | — | 1 | 8.46 |
| CHEMBL45102 | — | — | 1 | 8.42 |
| CHEMBL44925 | — | — | 1 | 8.38 |
| CHEMBL430570 | — | — | 1 | 8.38 |
| CHEMBL47187 | — | — | 1 | 8.37 |
| CHEMBL295966 | — | — | 1 | 8.34 |
| CHEMBL290907 | — | — | 1 | 8.34 |
| CHEMBL42287 | — | — | 1 | 8.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295854 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL295928 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL43535 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL418625 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL288246 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL42775 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL291043 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL46822 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL43424 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL43500 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL297358 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL289291 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL42397 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL289507 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL298417 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL7550 | L-158809 | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL290248 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL296472 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL295456 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL429008 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL298464 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL45195 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL43171 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL45102 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL44925 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL430570 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL47187 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL295966 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL290907 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL42287 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL295929 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL42101 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL42184 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL288705 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL289448 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL42631 | — | IC50 | = | 56.0 | nM | 7.25 |