Assay Detail
Binding
CHEMBL876744
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Displacement of monoiodinated angiotensin II from guinea-pig adrenal gland angiotensin II receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Adrenal gland |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
The synthesis of heterosubstituted benzimidazole derivatives with potent angiotensin II antagonist activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.51 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7550 | L-158809 | — | 1 | 8.22 |
| CHEMBL429008 | — | — | 1 | 7.80 |
| CHEMBL267056 | — | — | 1 | 7.77 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.75 |
| CHEMBL7478 | — | — | 1 | 7.66 |
| CHEMBL7641 | — | — | 1 | 7.02 |
| CHEMBL7826 | — | — | 1 | 6.59 |
| CHEMBL7396 | — | — | 1 | 5.67 |
| CHEMBL7632 | — | — | 1 | 5.64 |
| CHEMBL7431 | — | — | 1 | 5.00 |
| CHEMBL7369 | — | — | 1 | 5.00 |
| CHEMBL268822 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7550 | L-158809 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL429008 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL267056 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL191 | LOSARTAN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL7478 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL7641 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL7826 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL7396 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL7632 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL7431 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL7369 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL268822 | — | IC50 | = | 100000.0 | nM | 4.00 |