Assay Detail
Binding
CHEMBL649498
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Inhibitory activity against Angiotensin II receptor, type 1 in rat aortic membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.47 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158725 | — | — | 1 | 9.22 |
| CHEMBL41194 | PRATOSARTAN | 2.0 | 1 | 9.10 |
| CHEMBL43591 | — | — | 1 | 8.26 |
| CHEMBL71162 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158725 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL41194 | PRATOSARTAN | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL43591 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL71162 | — | IC50 | = | 52.0 | nM | 7.28 |