Compound Detail
CHEMBL41194
PRATOSARTAN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL41194 |
| Name | PRATOSARTAN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | KCTFTBCZZUBAKN-UHFFFAOYSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
7
Publications
5
Known Names
4
Mechanisms
Molecular Properties
426.5
MW (Da)
4.64
ALogP
6
HBA
1
HBD
89.3
PSA (Ų)
0.45
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Type-1 angiotensin II receptor antagonist | ANTAGONIST | Type-1 angiotensin II receptor | ✓ | ✓ |
| Solute carrier family 22 member 12 inhibitor | INHIBITOR | Solute carrier family 22 member 12 | ✓ | ✓ |
| Solute carrier family 22 member 6 inhibitor | INHIBITOR | Solute carrier family 22 member 6 | ✓ | ✓ |
| Solute carrier family 22 member 8 inhibitor | INHIBITOR | Organic anion transporter 3 | ✓ | ✓ |
Activity Summary
Kd 4 meas. best 10.04
IC50 2 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor CHEMBL2094256 | Kd | 10.04 | 10.03 | 0.1 | 3 |
| Type-1 angiotensin II receptor CHEMBL3948 | Kd | 10.04 | 10.04 | 0.1 | 1 |
| Angiotensin II receptor (AT-1) type-1 CHEMBL2094250 | IC50 | 9.1 | 9.1 | 0.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin II receptor | Kd | = | 0.0912 | nM | 10.04 | Displacement of angiotensin II from angiotensin II receptor of rabbit aorta | - |
| Angiotensin II receptor | Kd | = | 0.0912 | nM | 10.04 | Inhibition of angiotensin II-induced contractions in rabbit aorta in vitro. | 8576904 |
| Type-1 angiotensin II receptor | Kd | = | 0.0912 | nM | 10.04 | Antagonist activity at angiotensin AT1 receptor in rabbit aorta | 21071232 |
| Angiotensin II receptor | Kd | = | 0.09772 | nM | 10.01 | Evaluated in vitro for antagonism of AII induced contraction of isolated rabbit ... | - |
| Angiotensin II receptor (AT-1) type-1 | IC50 | = | 0.8 | nM | 9.1 | Inhibitory concentration required against binding of [125I]Sar, Ile- Angiotensin... | - |
| Angiotensin II receptor (AT-1) type-1 | IC50 | = | 0.8 | nM | 9.1 | Inhibitory activity against Angiotensin II receptor, type 1 in rat aortic membra... | 8576904 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80018-9 | Angiotensin II receptor | 1 |
| - | 10.1016/S0960-894X(00)80018-9 | Angiotensin II receptor (AT-1) type-1 | 1 |
| - | 10.1016/S0960-894X(00)80018-9 | Type-2 angiotensin II receptor | 1 |
| - | 10.1016/S0960-894X(01)80581-3 | Angiotensin II receptor | 1 |
| 8576904 | 10.1021/jm9504722 | Angiotensin II receptor (AT-1) type-1 | 1 |
| 8576904 | 10.1021/jm9504722 | Angiotensin II receptor | 1 |
| 21071232 | 10.1016/j.bmc.2010.10.043 | Type-1 angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine