Assay Detail
Functional
CHEMBL770464
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Inhibition of angiotensin II-induced contractions in rabbit aorta in vitro.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 21 | 8.77 | 10.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47177 | — | — | 1 | 10.90 |
| CHEMBL416477 | — | — | 1 | 10.70 |
| CHEMBL293511 | — | — | 1 | 10.30 |
| CHEMBL418226 | — | — | 1 | 10.30 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 10.09 |
| CHEMBL41194 | PRATOSARTAN | 2.0 | 1 | 10.04 |
| CHEMBL433895 | — | — | 1 | 9.20 |
| CHEMBL48602 | — | — | 1 | 9.00 |
| CHEMBL352257 | — | — | 1 | 8.82 |
| CHEMBL71162 | — | — | 1 | 8.70 |
| CHEMBL347610 | — | — | 1 | 8.65 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.48 |
| CHEMBL158725 | — | — | 1 | 8.45 |
| CHEMBL432162 | TASOSARTAN | 2.0 | 1 | 8.40 |
| CHEMBL284536 | — | — | 1 | 8.30 |
| CHEMBL315021 | FORASARTAN | 2.0 | 1 | 8.18 |
| CHEMBL275875 | CL-329167 | — | 1 | 8.01 |
| CHEMBL262958 | — | — | 1 | 7.20 |
| CHEMBL341716 | — | — | 1 | 7.10 |
| CHEMBL158794 | — | — | 1 | 6.90 |
| CHEMBL25686 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47177 | — | Kd | = | 0.01259 | nM | 10.90 |
| CHEMBL416477 | — | Kd | = | 0.01995 | nM | 10.70 |
| CHEMBL293511 | — | Kd | = | 0.05012 | nM | 10.30 |
| CHEMBL418226 | — | Kd | = | 0.05012 | nM | 10.30 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | Kd | = | 0.08128 | nM | 10.09 |
| CHEMBL41194 | PRATOSARTAN | Kd | = | 0.0912 | nM | 10.04 |
| CHEMBL433895 | — | Kd | = | 0.631 | nM | 9.20 |
| CHEMBL48602 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL352257 | — | Kd | = | 1.514 | nM | 8.82 |
| CHEMBL71162 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL347610 | — | Kd | = | 2.239 | nM | 8.65 |
| CHEMBL191 | LOSARTAN | Kd | = | 3.311 | nM | 8.48 |
| CHEMBL158725 | — | Kd | = | 3.548 | nM | 8.45 |
| CHEMBL432162 | TASOSARTAN | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL284536 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL315021 | FORASARTAN | Kd | = | 6.607 | nM | 8.18 |
| CHEMBL275875 | CL-329167 | Kd | = | 9.772 | nM | 8.01 |
| CHEMBL262958 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL341716 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL158794 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL25686 | — | Kd | = | 288.4 | nM | 6.54 |