Assay Detail
Binding
CHEMBL652260
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Displacement of angiotensin II from angiotensin II receptor of rabbit aorta
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
4,5,6,7-Tetrahdryo-8-oxo-cycloheptimidazoles: a new class of potent non-peptide angiiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 8.16 | 10.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41194 | PRATOSARTAN | 2.0 | 1 | 10.04 |
| CHEMBL40340 | — | — | 1 | 9.66 |
| CHEMBL40286 | — | — | 1 | 9.36 |
| CHEMBL41826 | — | — | 1 | 9.04 |
| CHEMBL17196 | — | — | 1 | 8.32 |
| CHEMBL287841 | — | — | 1 | 8.31 |
| CHEMBL43360 | — | — | 1 | 8.13 |
| CHEMBL288506 | — | — | 1 | 7.80 |
| CHEMBL41828 | — | — | 1 | 7.69 |
| CHEMBL41448 | — | — | 1 | 7.41 |
| CHEMBL39642 | — | — | 1 | 7.33 |
| CHEMBL290917 | — | — | 1 | 7.23 |
| CHEMBL291087 | — | — | 1 | 7.04 |
| CHEMBL40549 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41194 | PRATOSARTAN | Kd | = | 0.0912 | nM | 10.04 |
| CHEMBL40340 | — | Kd | = | 0.2188 | nM | 9.66 |
| CHEMBL40286 | — | Kd | = | 0.4365 | nM | 9.36 |
| CHEMBL41826 | — | Kd | = | 0.912 | nM | 9.04 |
| CHEMBL17196 | — | Kd | = | 4.786 | nM | 8.32 |
| CHEMBL287841 | — | Kd | = | 4.898 | nM | 8.31 |
| CHEMBL43360 | — | Kd | = | 7.413 | nM | 8.13 |
| CHEMBL288506 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL41828 | — | Kd | = | 20.42 | nM | 7.69 |
| CHEMBL41448 | — | Kd | = | 38.9 | nM | 7.41 |
| CHEMBL39642 | — | Kd | = | 46.77 | nM | 7.33 |
| CHEMBL290917 | — | Kd | = | 58.88 | nM | 7.23 |
| CHEMBL291087 | — | Kd | = | 91.2 | nM | 7.04 |
| CHEMBL40549 | — | Kd | = | 144.54 | nM | 6.84 |