Assay Detail
Functional
CHEMBL652261
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Evaluated in vitro for antagonism of AII induced contraction of isolated rabbit aorta
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cycloheptimidazole based angiotensin II receptor antagonists. 4,5,6,7-tetrahydro-8-carboxymethylidene cycloheptimidazoles
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 8.66 | 10.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41194 | PRATOSARTAN | 2.0 | 1 | 10.01 |
| CHEMBL44295 | — | — | 1 | 9.80 |
| CHEMBL289391 | — | — | 1 | 9.80 |
| CHEMBL43540 | — | — | 1 | 9.66 |
| CHEMBL43530 | — | — | 1 | 9.64 |
| CHEMBL290848 | — | — | 1 | 9.52 |
| CHEMBL443000 | — | — | 1 | 9.30 |
| CHEMBL288832 | — | — | 1 | 9.03 |
| CHEMBL297637 | — | — | 1 | 8.90 |
| CHEMBL298080 | — | — | 1 | 8.80 |
| CHEMBL42984 | — | — | 1 | 8.02 |
| CHEMBL43861 | — | — | 1 | 7.85 |
| CHEMBL43814 | — | — | 1 | 7.00 |
| CHEMBL46628 | — | — | 1 | 6.31 |
| CHEMBL42070 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41194 | PRATOSARTAN | Kd | = | 0.09772 | nM | 10.01 |
| CHEMBL44295 | — | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL289391 | — | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL43540 | — | Kd | = | 0.2188 | nM | 9.66 |
| CHEMBL43530 | — | Kd | = | 0.2291 | nM | 9.64 |
| CHEMBL290848 | — | Kd | = | 0.302 | nM | 9.52 |
| CHEMBL443000 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL288832 | — | Kd | = | 0.9333 | nM | 9.03 |
| CHEMBL297637 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL298080 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL42984 | — | Kd | = | 9.55 | nM | 8.02 |
| CHEMBL43861 | — | Kd | = | 14.13 | nM | 7.85 |
| CHEMBL43814 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL46628 | — | Kd | = | 489.78 | nM | 6.31 |
| CHEMBL42070 | — | Kd | = | 588.84 | nM | 6.23 |