Assay Detail
Binding
CHEMBL649503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against [125 I]Ang II binding to rat pituitary membranes Angiotensin II receptor type 1 without 0.2% bovine serum albumin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and biological activities of four angiotensin II receptor ligands with gamma-turn mimetics replacing amino acid residues 3-5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.72 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413740 | — | — | 1 | 9.05 |
| CHEMBL411997 | — | — | 1 | 8.77 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.74 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 8.70 |
| CHEMBL1791261 | — | — | 1 | 8.70 |
| CHEMBL1791267 | — | — | 1 | 8.55 |
| CHEMBL405464 | — | — | 1 | 8.54 |
| CHEMBL1791259 | — | — | 1 | - |
| CHEMBL1791262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413740 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL411997 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL191 | LOSARTAN | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL408403 | ANGIOTENSIN II | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1791261 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1791267 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL405464 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL1791259 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1791262 | — | IC50 | > | 100000.0 | nM | - |