Assay Detail
Binding
CHEMBL649530
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Inhibitory activity against binding of [125I]IMSB to amyloid beta in brain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.80 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74704 | — | — | 1 | 9.96 |
| CHEMBL76112 | — | — | 1 | 9.89 |
| CHEMBL300172 | CHRYSAMINE G | — | 1 | 9.85 |
| CHEMBL305634 | — | — | 1 | 9.72 |
| CHEMBL74348 | — | — | 1 | 9.57 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74704 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL76112 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL300172 | CHRYSAMINE G | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL305634 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL74348 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL424 | SALICYLIC ACID | Ki | > | 1800.0 | nM | - |