Assay Detail
Binding
CHEMBL649707
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Inhibition of Angiotensin II receptor, type 1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.90 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74476 | — | — | 1 | 9.62 |
| CHEMBL158795 | — | — | 1 | 9.52 |
| CHEMBL302519 | — | — | 1 | 9.48 |
| CHEMBL292150 | — | — | 1 | 9.35 |
| CHEMBL73876 | — | — | 1 | 9.24 |
| CHEMBL71925 | — | — | 1 | 9.22 |
| CHEMBL302102 | — | — | 1 | 8.77 |
| CHEMBL59957 | — | — | 1 | 8.72 |
| CHEMBL24861 | — | — | 1 | 8.60 |
| CHEMBL159004 | — | — | 1 | 8.30 |
| CHEMBL135089 | — | — | 1 | 8.28 |
| CHEMBL123562 | — | — | 1 | 7.72 |
| CHEMBL279629 | L-159913 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74476 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL158795 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL302519 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL292150 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL73876 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL71925 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL302102 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL59957 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL24861 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL159004 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL135089 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL123562 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL279629 | L-159913 | IC50 | = | 500.0 | nM | - |