Assay Detail
Binding
CHEMBL649708
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Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.74 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24322 | — | — | 1 | 10.00 |
| CHEMBL293511 | — | — | 1 | 9.70 |
| CHEMBL7550 | L-158809 | — | 1 | 9.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24322 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL293511 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL7550 | L-158809 | IC50 | = | 0.3 | nM | 9.52 |