Assay Detail
Binding
CHEMBL649712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
A new class of balanced AT1/AT2 angiotensin II antagonists: quinazolinone AII antagonists with acylsulfonamide and sulfonylcarbamate acidic functionalities
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 9.30 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353037 | — | — | 1 | 9.92 |
| CHEMBL353800 | — | — | 1 | 9.82 |
| CHEMBL352771 | — | — | 1 | 9.82 |
| CHEMBL354779 | — | — | 1 | 9.77 |
| CHEMBL169568 | — | — | 1 | 9.74 |
| CHEMBL169221 | — | — | 1 | 9.74 |
| CHEMBL352503 | — | — | 1 | 9.72 |
| CHEMBL169967 | — | — | 1 | 9.68 |
| CHEMBL74476 | — | — | 1 | 9.62 |
| CHEMBL169488 | — | — | 1 | 9.62 |
| CHEMBL168413 | — | — | 1 | 9.60 |
| CHEMBL353615 | — | — | 1 | 9.60 |
| CHEMBL169968 | — | — | 1 | 9.60 |
| CHEMBL168490 | — | — | 1 | 9.59 |
| CHEMBL352629 | — | — | 1 | 9.49 |
| CHEMBL352947 | — | — | 1 | 9.48 |
| CHEMBL352502 | — | — | 1 | 9.46 |
| CHEMBL352458 | — | — | 1 | 9.44 |
| CHEMBL169279 | — | — | 1 | 9.41 |
| CHEMBL354080 | — | — | 1 | 9.37 |
| CHEMBL353980 | — | — | 1 | 9.26 |
| CHEMBL169009 | — | — | 1 | 9.07 |
| CHEMBL168771 | — | — | 1 | 9.00 |
| CHEMBL354298 | — | — | 1 | 8.96 |
| CHEMBL168346 | — | — | 1 | 7.82 |
| CHEMBL169798 | — | — | 1 | 7.80 |
| CHEMBL169827 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353037 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL353800 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL352771 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL354779 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL169568 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL169221 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL352503 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL169967 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL74476 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL169488 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL168413 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL353615 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL169968 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL168490 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL352629 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL352947 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL352502 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL352458 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL169279 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL354080 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL353980 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL169009 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL168771 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL354298 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL168346 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL169798 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL169827 | — | IC50 | = | 180.0 | nM | 6.75 |