Assay Detail
Binding
CHEMBL649836
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against rat prostate cytosolic Androgen receptor using [3H]mibolerone as radioligand
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.14 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425863 | MIBOLERONE | 2.0 | 1 | 9.12 |
| CHEMBL386630 | TESTOSTERONE | 4.0 | 1 | 8.31 |
| CHEMBL9389 | — | — | 1 | 7.89 |
| CHEMBL9337 | RU-58841 | — | 1 | 7.58 |
| CHEMBL428309 | — | — | 1 | 7.43 |
| CHEMBL266786 | — | — | 1 | 7.19 |
| CHEMBL432658 | — | — | 1 | 6.92 |
| CHEMBL9146 | — | — | 1 | 6.91 |
| CHEMBL274667 | — | — | 1 | 6.85 |
| CHEMBL9447 | — | — | 1 | 6.82 |
| CHEMBL9328 | — | — | 1 | 6.67 |
| CHEMBL9140 | — | — | 1 | 6.49 |
| CHEMBL268214 | — | — | 1 | 6.44 |
| CHEMBL269372 | — | — | 1 | 6.38 |
| CHEMBL9390 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425863 | MIBOLERONE | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL386630 | TESTOSTERONE | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL9389 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL9337 | RU-58841 | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL428309 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL266786 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL432658 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL9146 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL274667 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL9447 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL9328 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL9140 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL268214 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL269372 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL9390 | — | Ki | = | 809.0 | nM | 6.09 |