Assay Detail
Functional
CHEMBL650030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound is tested for the inhibition of Forskolin-induced cAMP accumulation in BHK cells expressing the human sst4 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mesocricetus auratus |
| Cell Type | BHK |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.51 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142986 | — | — | 1 | 7.62 |
| CHEMBL103769 | — | — | 1 | 7.58 |
| CHEMBL143245 | — | — | 1 | 6.81 |
| CHEMBL142402 | — | — | 1 | 6.00 |
| CHEMBL142422 | — | — | 1 | 5.63 |
| CHEMBL142613 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142986 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL103769 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL143245 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL142402 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL142422 | — | EC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL142613 | — | EC50 | = | 4000.0 | nM | 5.40 |