Compound Detail
CHEMBL143245
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Basic Information
| ChEMBL ID | CHEMBL143245 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LSBNBXGDMFDJPP-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
582.4
MW (Da)
5.91
ALogP
5
HBA
3
HBD
65.1
PSA (Ų)
0.18
QED
2
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.81
Ki 1 meas. best 6.73
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ADMET CHEMBL612558 | EC50 | 6.81 | 6.81 | 154.0 | 1 |
| Somatostatin receptor type 4 CHEMBL1853 | Ki | 6.73 | 6.73 | 185.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ADMET | EC50 | = | 154.0 | nM | 6.81 | Compound is tested for the inhibition of Forskolin-induced cAMP accumulation in ... | 9822540 |
| Somatostatin receptor type 4 | Ki | = | 185.0 | nM | 6.73 | In vitro binding affinity at somatostatin receptor 4 in transfected BHK cells us... | 9822540 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9822540 | 10.1021/jm980118e | Somatostatin receptor type 2 | 1 |
| 9822540 | 10.1021/jm980118e | Somatostatin receptor type 4 | 1 |
| 9822540 | 10.1021/jm980118e | ADMET | 1 |
Data from ChEMBL 36 via Core Engine