Assay Detail
Functional
CHEMBL650213
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Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.13 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43711 | — | — | 1 | 7.40 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 7.28 |
| CHEMBL287587 | — | — | 1 | 7.20 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 6.64 |
| CHEMBL281232 | — | — | 1 | - |
| CHEMBL42359 | — | — | 1 | - |
| CHEMBL435802 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43711 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL287587 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL679 | EPINEPHRINE | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL281232 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL42359 | — | EC50 | > | 1500.0 | nM | - |
| CHEMBL435802 | — | EC50 | > | 100000.0 | nM | - |