Assay Detail
Binding
CHEMBL650269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
L-162,389: a potent orally active angiotensin II receptor antagonist with balanced affinity to both AT1 and AT2 receptor subtypes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.33 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318605 | — | — | 1 | 9.70 |
| CHEMBL105199 | — | — | 1 | 9.70 |
| CHEMBL293511 | — | — | 1 | 9.70 |
| CHEMBL449095 | — | — | 1 | 8.85 |
| CHEMBL39959 | — | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318605 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL105199 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL293511 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL449095 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL39959 | — | IC50 | = | 2.1 | nM | 8.68 |