Assay Detail
Binding
CHEMBL650270
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Synthesis and structure-activity relationships of a novel series of non-peptide AT2-selective angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.54 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292939 | — | — | 1 | 4.68 |
| CHEMBL293195 | — | — | 1 | 4.60 |
| CHEMBL60209 | — | — | 1 | 4.35 |
| CHEMBL299887 | — | — | 1 | - |
| CHEMBL59913 | — | — | 1 | - |
| CHEMBL64714 | — | — | 1 | - |
| CHEMBL64881 | — | — | 1 | - |
| CHEMBL293625 | — | — | 1 | - |
| CHEMBL64280 | — | — | 1 | - |
| CHEMBL277567 | — | — | 1 | - |
| CHEMBL62157 | — | — | 1 | - |
| CHEMBL290829 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292939 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL293195 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL60209 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL299887 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL59913 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL64714 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL64881 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL293625 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64280 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL277567 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL62157 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL290829 | — | IC50 | > | 100000.0 | nM | - |