Assay Detail
Binding
CHEMBL650273
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Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
L-161,638: A potent AT2selective quinazolinone angiotensin II binding inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.28 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24322 | — | — | 1 | 10.00 |
| CHEMBL287250 | — | — | 1 | 8.77 |
| CHEMBL108981 | — | — | 1 | 8.31 |
| CHEMBL37919 | — | — | 1 | 8.29 |
| CHEMBL290768 | — | — | 1 | 7.38 |
| CHEMBL34082 | — | — | 1 | 7.14 |
| CHEMBL276853 | — | — | 1 | 7.10 |
| CHEMBL284123 | — | — | 1 | 6.80 |
| CHEMBL35638 | — | — | 1 | 6.77 |
| CHEMBL289472 | — | — | 1 | 6.70 |
| CHEMBL285433 | — | — | 1 | 6.39 |
| CHEMBL285432 | — | — | 1 | 6.23 |
| CHEMBL35324 | — | — | 1 | 6.09 |
| CHEMBL290669 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24322 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL287250 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL108981 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL37919 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL290768 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL34082 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL276853 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL284123 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL35638 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL289472 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL285433 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL285432 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL35324 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL290669 | — | IC50 | = | 1200.0 | nM | 5.92 |