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Assay Detail

CHEMBL650300

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Binding
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Type-1 angiotensin II receptor (CHEMBL3374)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Angiotensin analogues palmitoylated in positions 1 and 4.
Maletínská L, Neugebauer W, Pérodin J, Lefebvre M, Escher E.
J Med Chem (1997) 40 : 3271 -3279
PubMed 9379447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 14 6.99 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428475 1 8.85
CHEMBL415157 1 8.45
CHEMBL408403 ANGIOTENSIN II 4.0 1 8.24
CHEMBL412717 1 8.12
CHEMBL268804 1 7.78
CHEMBL406519 1 7.75
CHEMBL265681 1 6.98
CHEMBL384349 1 6.65
CHEMBL264230 1 6.49
CHEMBL406888 1 6.31
CHEMBL408098 1 5.81
CHEMBL402669 1 5.65
CHEMBL405031 1 5.56
CHEMBL411624 1 5.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428475 Kd = 1.413 nM 8.85
CHEMBL415157 Kd = 3.548 nM 8.45
CHEMBL408403 ANGIOTENSIN II Kd = 5.754 nM 8.24
CHEMBL412717 Kd = 7.586 nM 8.12
CHEMBL268804 Kd = 16.6 nM 7.78
CHEMBL406519 Kd = 17.78 nM 7.75
CHEMBL265681 Kd = 104.71 nM 6.98
CHEMBL384349 Kd = 223.87 nM 6.65
CHEMBL264230 Kd = 323.59 nM 6.49
CHEMBL406888 Kd = 489.78 nM 6.31
CHEMBL408098 Kd = 1548.82 nM 5.81
CHEMBL402669 Kd = 2238.72 nM 5.65
CHEMBL405031 Kd = 2754.23 nM 5.56
CHEMBL411624 Kd = 6456.54 nM 5.19