Assay Detail
Binding
CHEMBL650820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]- flunitrazepam binding to GABA-A benzodiazepine receptor of bovine cortical membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2094107) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
Publication
Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.52 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146633 | — | — | 1 | 7.92 |
| CHEMBL146761 | — | — | 1 | 7.19 |
| CHEMBL145881 | — | — | 1 | 6.24 |
| CHEMBL357164 | — | — | 1 | 6.09 |
| CHEMBL356061 | — | — | 1 | 5.90 |
| CHEMBL146389 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146633 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL146761 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL145881 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL357164 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL356061 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL146389 | — | Ki | = | 1800.0 | nM | 5.75 |