Compound Detail
CHEMBL146389
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Basic Information
| ChEMBL ID | CHEMBL146389 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HDDCQKJMNNOBJT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
325.3
MW (Da)
2.60
ALogP
5
HBA
3
HBD
125.3
PSA (Ų)
0.22
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL2094107 | Ki | 5.75 | 5.75 | 1800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 1800.0 | nM | 5.75 | In vitro inhibition of [3H]- flunitrazepam binding to GABA-A benzodiazepine rece... | 8978839 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8978839 | 10.1021/jm960240i | GABA-A receptor; anion channel | 3 |
Data from ChEMBL 36 via Core Engine