Assay Detail
Binding
CHEMBL651192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for beta adrenergic binding affinity towards beta-2 receptor of bovine lung
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.72 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 6.96 |
| CHEMBL7160 | — | — | 1 | 6.92 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 5.22 |
| CHEMBL7681 | — | — | 1 | 5.04 |
| CHEMBL268881 | — | — | 1 | 4.44 |
| CHEMBL7278 | — | — | 1 | - |
| CHEMBL6898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL7160 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL7681 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL268881 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL7278 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL6898 | — | Ki | > | 100000.0 | nM | - |