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Assay Detail

CHEMBL651487

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Concentration that inhibits specific [3H]flunitrazepam binding to benzodiazepine receptor in bovine brain
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

GABA-A receptor; anion channel (CHEMBL2094107)
Type PROTEIN COMPLEX GROUP
Organism Bos taurus

Publication

beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid.
Lippke KP, Schunack WG, Wenning W, Müller WE.
J Med Chem (1983) 26 : 499 -503
PubMed 6300400 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.88 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL11709 1 8.85
CHEMBL453066 BETA-CCM 1 8.60
CHEMBL274847 1 8.34
CHEMBL2051966 1 8.28
CHEMBL358965 1 7.68
CHEMBL147696 1 7.66
CHEMBL343450 1 7.57
CHEMBL145912 1 7.57
CHEMBL148296 1 7.54
CHEMBL356048 1 7.47
CHEMBL147919 1 6.84
CHEMBL358326 1 6.60
CHEMBL356991 1 6.48
CHEMBL1203388 1 5.57
CHEMBL147720 1 5.36
CHEMBL146126 1 5.32
CHEMBL146667 1 5.22
CHEMBL11908 1 5.14
CHEMBL149177 1 4.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL11709 IC50 = 1.4 nM 8.85
CHEMBL453066 BETA-CCM IC50 = 2.5 nM 8.60
CHEMBL274847 IC50 = 4.6 nM 8.34
CHEMBL2051966 IC50 = 5.3 nM 8.28
CHEMBL358965 IC50 = 21.0 nM 7.68
CHEMBL147696 IC50 = 22.0 nM 7.66
CHEMBL343450 IC50 = 27.0 nM 7.57
CHEMBL145912 IC50 = 27.0 nM 7.57
CHEMBL148296 IC50 = 29.0 nM 7.54
CHEMBL356048 IC50 = 34.0 nM 7.47
CHEMBL147919 IC50 = 145.0 nM 6.84
CHEMBL358326 IC50 = 250.0 nM 6.60
CHEMBL356991 IC50 = 330.0 nM 6.48
CHEMBL1203388 IC50 = 2700.0 nM 5.57
CHEMBL147720 IC50 = 4400.0 nM 5.36
CHEMBL146126 IC50 = 4800.0 nM 5.32
CHEMBL146667 IC50 = 6000.0 nM 5.22
CHEMBL11908 IC50 = 7200.0 nM 5.14
CHEMBL149177 IC50 = 22000.0 nM 4.66