Compound Detail
CHEMBL358326
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Basic Information
| ChEMBL ID | CHEMBL358326 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QZGCHMZBGHVZFB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
230.3
MW (Da)
1.36
ALogP
3
HBA
2
HBD
54.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL2094107 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | IC50 | = | 250.0 | nM | 6.6 | Concentration that inhibits specific [3H]flunitrazepam binding to benzodiazepine... | 6300400 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21060288 | 10.3390/molecules15117775 | Culex quinquefasciatus | 3 |
| 6300400 | 10.1021/jm00358a008 | GABA-A receptor; anion channel | 2 |
| 21060288 | 10.3390/molecules15117775 | Lipaphis erysimi | 1 |
| 25819098 | 10.1016/j.bmcl.2015.03.014 | Tyrosine-protein phosphatase non-receptor type 1 | 1 |
| 29960728 | 10.1016/j.bmc.2018.06.018 | Cholinesterase | 1 |
| 29960728 | 10.1016/j.bmc.2018.06.018 | Acetylcholinesterase | 1 |
| 29960728 | 10.1016/j.bmc.2018.06.018 | Unchecked | 1 |
| 29960728 | 10.1016/j.bmc.2018.06.018 | Amyloid-beta precursor protein | 1 |
Data from ChEMBL 36 via Core Engine