Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL652259

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro antagonist activity against rat prostatic androgen receptor (AR)
ChEMBL ↗
132
Total Activities
130
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Androgen receptor (CHEMBL3072) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding.
Rasmusson GH, Reynolds GF, Steinberg NG, Walton E, Patel GF, Liang T, Cascieri MA, Cheung AH, Brooks JR, Berman C.
J Med Chem (1986) 29 : 2298 -2315
PubMed 3783591 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 132 6.13 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3349077 — — 1 8.82
CHEMBL27769 STANOLONE 2.0 1 8.66
CHEMBL559246 — — 1 8.62
CHEMBL386630 TESTOSTERONE 4.0 1 8.49
CHEMBL3349086 — — 1 8.13
CHEMBL3349122 — — 1 7.92
CHEMBL3349134 — — 1 7.89
CHEMBL3349148 — — 1 7.82
CHEMBL2311174 — — 1 7.72
CHEMBL1230438 — — 1 7.70
CHEMBL3349210 — — 1 7.64
CHEMBL3349120 — — 1 7.52
CHEMBL3349150 — — 1 7.19
CHEMBL274826 ANDROSTENEDIONE -1.0 1 7.19
CHEMBL2298410 — — 1 7.18
CHEMBL1790280 — — 1 7.13
CHEMBL584295 — — 1 7.08
CHEMBL3349146 — — 1 7.05
CHEMBL3349100 — — 1 7.05
CHEMBL3349114 — — 1 7.05
CHEMBL3349095 — — 1 7.00
CHEMBL3349087 — — 1 6.96
CHEMBL3349116 — — 1 6.92
CHEMBL3349105 — — 1 6.89
CHEMBL3349293 — — 1 6.85
CHEMBL3349078 — — 1 6.85
CHEMBL3349165 — — 1 6.82
CHEMBL3349180 — — 2 6.82
CHEMBL3349160 — — 1 6.82
CHEMBL583743 — — 1 6.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3349077 — IC50 = 1.5 nM 8.82
CHEMBL27769 STANOLONE IC50 = 2.2 nM 8.66
CHEMBL559246 — IC50 = 2.4 nM 8.62
CHEMBL386630 TESTOSTERONE IC50 = 3.2 nM 8.49
CHEMBL3349086 — IC50 = 7.4 nM 8.13
CHEMBL3349122 — IC50 = 12.0 nM 7.92
CHEMBL3349134 — IC50 = 13.0 nM 7.89
CHEMBL3349148 — IC50 = 15.0 nM 7.82
CHEMBL2311174 — IC50 = 19.0 nM 7.72
CHEMBL1230438 — IC50 = 20.0 nM 7.70
CHEMBL3349210 — IC50 = 23.0 nM 7.64
CHEMBL3349120 — IC50 = 30.0 nM 7.52
CHEMBL3349150 — IC50 = 64.0 nM 7.19
CHEMBL274826 ANDROSTENEDIONE IC50 = 64.0 nM 7.19
CHEMBL2298410 — IC50 = 66.0 nM 7.18
CHEMBL1790280 — IC50 = 74.0 nM 7.13
CHEMBL584295 — IC50 = 83.0 nM 7.08
CHEMBL3349100 — IC50 = 89.0 nM 7.05
CHEMBL3349146 — IC50 = 89.0 nM 7.05
CHEMBL3349114 — IC50 = 89.0 nM 7.05
CHEMBL3349095 — IC50 = 100.0 nM 7.00
CHEMBL3349087 — IC50 = 110.0 nM 6.96
CHEMBL3349116 — IC50 = 120.0 nM 6.92
CHEMBL3349105 — IC50 = 130.0 nM 6.89
CHEMBL3349293 — IC50 = 140.0 nM 6.85
CHEMBL3349078 — IC50 = 140.0 nM 6.85
CHEMBL3349160 — IC50 = 150.0 nM 6.82
CHEMBL3349180 — IC50 = 150.0 nM 6.82
CHEMBL3349165 — IC50 = 150.0 nM 6.82
CHEMBL3349113 — IC50 = 170.0 nM 6.77
CHEMBL583743 — IC50 = 170.0 nM 6.77
CHEMBL3349512 — IC50 = 190.0 nM 6.72
CHEMBL3349130 — IC50 = 210.0 nM 6.68
CHEMBL3349180 — IC50 = 240.0 nM 6.62
CHEMBL3349119 — IC50 = 250.0 nM 6.60
CHEMBL3349094 — IC50 = 270.0 nM 6.57
CHEMBL3349082 — IC50 = 290.0 nM 6.54
CHEMBL3349141 — IC50 = 290.0 nM 6.54
CHEMBL1563246 — IC50 = 330.0 nM 6.48
CHEMBL3349129 — IC50 = 340.0 nM 6.47
CHEMBL3349126 — IC50 = 340.0 nM 6.47
CHEMBL575767 — IC50 = 400.0 nM 6.40
CHEMBL3349144 — IC50 = 420.0 nM 6.38
CHEMBL1790287 — IC50 = 430.0 nM 6.37
CHEMBL3349104 — IC50 = 440.0 nM 6.36
CHEMBL572724 — IC50 = 450.0 nM 6.35
CHEMBL3349147 — IC50 = 500.0 nM 6.30
CHEMBL3349098 — IC50 = 540.0 nM 6.27
CHEMBL3085570 — IC50 = 560.0 nM 6.25
CHEMBL3349084 — IC50 = 580.0 nM 6.24