Assay Detail
Functional
CHEMBL652264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for antagonism of Angiotensin II-contracted rabbit aortic rings. Compound shows Non-competitive receptor Antagonism.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.98 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9599 | SC-55634 | — | 1 | 9.30 |
| CHEMBL430152 | — | — | 1 | 9.20 |
| CHEMBL427808 | — | — | 1 | 9.00 |
| CHEMBL274668 | — | — | 1 | 8.70 |
| CHEMBL267809 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9599 | SC-55634 | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL430152 | — | Kd | = | 0.631 | nM | 9.20 |
| CHEMBL427808 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL274668 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL267809 | — | Kd | = | 1.995 | nM | 8.70 |