Assay Detail
Binding
CHEMBL652267
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In vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
19
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Substituted lactam biphenyltetrazoles as angiotensin II mediated antihypertensives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 19 | 8.13 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122891 | — | — | 1 | 9.00 |
| CHEMBL48602 | — | — | 2 | 9.00 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.80 |
| CHEMBL170196 | — | — | 1 | 8.50 |
| CHEMBL49207 | — | — | 2 | 8.40 |
| CHEMBL422912 | — | — | 1 | 8.40 |
| CHEMBL51084 | — | — | 1 | 8.30 |
| CHEMBL123208 | — | — | 2 | 8.20 |
| CHEMBL425139 | — | — | 1 | 7.90 |
| CHEMBL49192 | — | — | 1 | 7.90 |
| CHEMBL48459 | — | — | 1 | 7.90 |
| CHEMBL296731 | — | — | 1 | 7.80 |
| CHEMBL122855 | — | — | 1 | 7.70 |
| CHEMBL299151 | — | — | 1 | 7.50 |
| CHEMBL49262 | — | — | 1 | 7.40 |
| CHEMBL51622 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48602 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL122891 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL191 | LOSARTAN | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL48602 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL170196 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL49207 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL422912 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL51084 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL123208 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL49207 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL123208 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL425139 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL49192 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL48459 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL296731 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL122855 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL299151 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL49262 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL51622 | — | Kd | = | 100.0 | nM | 7.00 |