Assay Detail
Binding
CHEMBL652312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to 50% inhibition in specific binding of [125- I]A-II to Angiotensin II receptor in rat uterine membrane
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Conformational restriction of angiotensin II: cyclic analogues having high potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.49 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373017 | — | — | 1 | 9.05 |
| CHEMBL263034 | — | — | 1 | 8.89 |
| CHEMBL411997 | — | — | 1 | 8.68 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 8.66 |
| CHEMBL413740 | — | — | 1 | 8.59 |
| CHEMBL408560 | — | — | 1 | 8.00 |
| CHEMBL405557 | — | — | 1 | 7.89 |
| CHEMBL268506 | — | — | 1 | 7.82 |
| CHEMBL403983 | — | — | 1 | 7.70 |
| CHEMBL405464 | — | — | 1 | 7.37 |
| CHEMBL263571 | — | — | 1 | 7.24 |
| CHEMBL268147 | — | — | 1 | 5.00 |
| CHEMBL264567 | — | — | 1 | 5.00 |
| CHEMBL414549 | — | — | 1 | 5.00 |
| CHEMBL387086 | — | — | 1 | - |
| CHEMBL437246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373017 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL263034 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL411997 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL408403 | ANGIOTENSIN II | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL413740 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL408560 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL405557 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL268506 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL403983 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL405464 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL263571 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL268147 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL264567 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL414549 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL387086 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL437246 | — | IC50 | - | nM | - |