Assay Detail
Functional
CHEMBL652487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human acute T-lymphoblastic CCRF-CEM leukemia cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 2. Synthesis, structure-activity relationships, and biological evaluation of substituted 5H-pyridophenoxazin-5-ones with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.97 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 8.52 |
| CHEMBL148576 | — | — | 1 | 8.15 |
| CHEMBL147017 | — | — | 1 | 8.00 |
| CHEMBL348701 | — | — | 1 | 8.00 |
| CHEMBL151423 | — | — | 1 | 8.00 |
| CHEMBL147140 | — | — | 1 | 7.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.52 |
| CHEMBL149774 | — | — | 1 | 7.30 |
| CHEMBL147392 | — | — | 1 | 7.16 |
| CHEMBL357353 | — | — | 1 | 7.00 |
| CHEMBL148592 | — | — | 1 | 6.60 |
| CHEMBL347271 | — | — | 1 | 6.52 |
| CHEMBL151875 | — | — | 1 | 6.10 |
| CHEMBL346174 | — | — | 1 | 5.82 |
| CHEMBL422497 | — | — | 1 | 4.66 |
| CHEMBL148722 | — | — | 1 | 4.46 |
| CHEMBL149317 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL148576 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL147017 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL348701 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL151423 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL147140 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL149774 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL147392 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL357353 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL148592 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL347271 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL151875 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL346174 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL422497 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL148722 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL149317 | — | IC50 | > | 50000.0 | nM | - |