Assay Detail
Functional
CHEMBL652603
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Effective concentration was evaluated against HSV-1 by using serum starved baby hamster kidney cells in a colorimetric viral yield assay.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mesocricetus auratus |
| Cell Type | BHK-21 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.16 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133490 | — | — | 1 | 6.10 |
| CHEMBL435976 | — | — | 1 | 5.89 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.70 |
| CHEMBL330978 | — | — | 1 | 5.51 |
| CHEMBL334514 | — | — | 1 | 5.22 |
| CHEMBL336783 | — | — | 1 | 5.22 |
| CHEMBL336374 | — | — | 1 | 4.89 |
| CHEMBL133759 | — | — | 1 | 4.77 |
| CHEMBL337406 | — | — | 1 | 4.58 |
| CHEMBL334347 | — | — | 1 | 4.55 |
| CHEMBL132114 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133490 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL435976 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL330978 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL334514 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL336783 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL336374 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL133759 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL337406 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL334347 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL132114 | — | EC50 | = | 50000.0 | nM | 4.30 |