Assay Detail
Binding
CHEMBL652721
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Quinazolinones 2: QSAR and in vivo characterization of AT1 selective AII antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.67 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24322 | — | — | 1 | 10.00 |
| CHEMBL25585 | — | — | 1 | 9.30 |
| CHEMBL26614 | — | — | 1 | 9.24 |
| CHEMBL287184 | — | — | 1 | 9.05 |
| CHEMBL422756 | — | — | 1 | 8.96 |
| CHEMBL26217 | — | — | 1 | 8.96 |
| CHEMBL24861 | — | — | 1 | 8.80 |
| CHEMBL280526 | — | — | 1 | 8.80 |
| CHEMBL24661 | — | — | 1 | 8.40 |
| CHEMBL25313 | — | — | 1 | 8.30 |
| CHEMBL26548 | — | — | 1 | 8.12 |
| CHEMBL281846 | — | — | 1 | 8.05 |
| CHEMBL286260 | — | — | 1 | 7.92 |
| CHEMBL24764 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24322 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL25585 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL26614 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL287184 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL422756 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL26217 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL24861 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL280526 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL24661 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL25313 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL26548 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL281846 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL286260 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL24764 | — | IC50 | = | 30.0 | nM | 7.52 |